PHARMACEUTICAL ANALYSIS IV (Competence)

'Learning objectives? To learn advanced NMR techniques: 2D-NMR and its applications to peptides, proteins and drug design; magnetic resonance spectroscopy and magnetic resonance imaging and their biomedical applications. To understand the basic principles of fluorescence and its applications to peptides, proteins and their interactions. To understand the basic principles and pharmaceutical and biomedical applications of tendem techniques. Major topics? This is course is designed for those interested in advanced methods of pharmaceutical analysis and structural elucidation. The principles, pharmaceutical and biomedical applications of the following methods will be discussed: principles of 2-dimensional NMR, analysis of 2D NMR spectra. 3D structure elucidation from 2D NMR. NMR of peptides and proteins. Structure elucidation of peptides and proteins. NMR in drug design. Principles of fluorescence spectroscopy. Fluorescence anisotropy, polarization. Application of fluorescence techniques in protein ligand interactions, fluorescence sensors, molecular biology applications and fluorescence imaging. Circular Dichroism. Principles and applications of magnetic resonance spectroscopy, magnetic resonance imaging and tandem techniques. The principles and biomedical applications of MRS and MRI as well as pharmaceutical and biomedical applications of tandem techniques will be covered. Combination of lectures, self-learning and problem-based learning. Target Students? Postgraduate with permission.'